Cytoadherence characteristics of Plasmodium falciparum isolates in Thailand using an in vitro human lung endothelial cells model.

B Traoré Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by B Traoré in
Current site
Google Scholar
PubMed Close
,
K Muanza Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by K Muanza in
Current site
Google Scholar
PubMed Close
,
S Looareesuwan Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by S Looareesuwan in
Current site
Google Scholar
PubMed Close
,
S Supavej Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by S Supavej in
Current site
Google Scholar
PubMed Close
,
S Khusmith Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by S Khusmith in
Current site
Google Scholar
PubMed Close
,
M Danis Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by M Danis in
Current site
Google Scholar
PubMed Close
,
P Viriyavejakul Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by P Viriyavejakul in
Current site
Google Scholar
PubMed Close
, and
F Gay Institut National de la Santé et de la Recherche Médicale Unite 511, Faculté de Médecine Pitié-Salpêtrière, Paris, France.

Search for other papers by F Gay in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.2000.62.38
Volume/Issue:
Volume 62: Issue 1
Page(s):
38–44
Restricted access
Get Permissions

Using an in vitro model of human lung endothelial cells, we studied different characteristics of Plasmodium falciparum isolates as potential factors for malaria severity in 2 Thai patient groups: 27 with complicated malaria and 42 with uncomplicated malaria. In regard to binding properties, no association existed between cytoadherence and rosette phenotypes (P = 0.1) and hypothrombocytemia increased the cytoadherence level (P = 0.007). Cytoadherence was significantly associated with malaria severity (P = 0.05) in contrast to rosette formation (P = 0.9). Intercellular adhesion molecule-1 and chondroitin-4-sulfate were major receptors of cytoadherence in those with complicated malaria compared with those with uncomplicated malaria (P < 10(-4)). Chondroitin-4-sulfate could act as a putative receptor for malaria complications in non-pregnant women. CD36 was the main receptor in patients with uncomplicated malaria (P < 10(-3)). Vascular cell adhesion molecule-1 and E-selectin played a minor role in 2 groups (P = 0.6). Qinghaosu derivatives were more efficient than other antimalarial drugs, but a positive correlation was observed between the 50% inhibitory concentrations of halofantrine and quinine and the number of adhesive parasitized red blood cells, suggesting their influence on cytoadherence.

Published Online:
Jan 2000
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 66 66 12
Full Text Views 334 117 0
PDF Downloads 77 20 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save