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No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine.
M van Vugt
M van Vugt
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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F Ezzet
F Ezzet
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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F Nosten
F Nosten
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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I Gathmann
I Gathmann
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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P Wilairatana
P Wilairatana
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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S Looareesuwan
S Looareesuwan
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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N J White
N J White
Shoklo Malaria Research Unit, Mae Sod, Thailand.
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Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1249 | 1095 | 174 |
| Full Text Views | 256 | 4 | 2 |
| PDF Downloads | 68 | 3 | 1 |