Response of cutaneous leishmaniasis (chiclero's ulcer) to treatment with meglumine antimoniate in Southeast Mexico.

A Vargas-GonzalezLaboratorio de Immunología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, México.

Search for other papers by A Vargas-Gonzalez in
Current site
Google Scholar
PubMed
Close
,
S B Canto-LaraLaboratorio de Immunología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, México.

Search for other papers by S B Canto-Lara in
Current site
Google Scholar
PubMed
Close
,
A G Damian-CentenoLaboratorio de Immunología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, México.

Search for other papers by A G Damian-Centeno in
Current site
Google Scholar
PubMed
Close
, and
F J Andrade-NarvaezLaboratorio de Immunología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, México.

Search for other papers by F J Andrade-Narvaez in
Current site
Google Scholar
PubMed
Close
Restricted access

Cutaneous leishmaniasis, known as chiclero's ulcer in southeastern Mexico, is characterized by a predominantly single, painless, ulcerated lesion, without lymphangitis or adenopathy. When located on the ear, it tends to become chronic, causing destruction of the pinna and disfigurement. It is caused predominantly by Leishmania (L.) mexicana. Although pentavalent antimonials (Sb5+) are the mainstay of leishmanial therapy and have been used for more than 50 years, dosage regimens have been repeatedly modified and the best one has not been fully identified. The main purpose of the present study was to investigate the response of chiclero's ulcer to treatment with meglumine antimoniate. One hundred five patients were treated with meglumine antimoniate at a daily dose of 1 ampule per day (425 mg of Sb5+) until healing. The lesions healed after a mean of 25 days (range = 5-60 days).

Save