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Long-term suppression of adult bladder morbidity and severe hydronephrosis following selective population chemotherapy for Schistosoma haematobium.
A K Subramanian
A K Subramanian
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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P Mungai
P Mungai
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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J H Ouma
J H Ouma
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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P Magak
P Magak
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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C H King
C H King
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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A A Mahmoud
A A Mahmoud
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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C L King
C L King
Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Ohio 44106-4983, USA.
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Repeated selective population chemotherapy of school age children reduces infection and morbidity associated with Schistosoma haematobium infection. To examine the long-term effect of this treatment on susceptibility to re-infection and late disease, a cohort of Kenyans (n = 194) were re-examined for infection and urinary tract morbidity 7-13 years after they underwent annual ultrasonography and treatment for an average of 5 years beginning in 1984 as children. Controls were previously untreated age-matched individuals residing in the same or adjacent villages. The overall prevalence and intensity of infection were equivalent between the 2 groups. In contrast, the prevalence of bladder wall pathology was 11-fold lower in previously treated (1.5%) versus untreated subjects (17%). Severe hydronephrosis was completely reversed. These data demonstrate that treatment significantly reduced urinary tract morbidity despite re-infection, and suggest that the important risk factors for urinary tract morbidity in adulthood are cumulative intensity and duration of infection during early adolescence.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 102 | 86 | 4 |
| Full Text Views | 229 | 1 | 0 |
| PDF Downloads | 39 | 1 | 0 |