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Plasmodium falciparum resistance to sulfadoxine/pyrimethamine in Uganda: correlation with polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes.
T Jelinek
T Jelinek
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
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A H Kilian
A H Kilian
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
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G Kabagambe
G Kabagambe
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
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F von Sonnenburg
F von Sonnenburg
Department of Infectious Diseases and Tropical Medicine, University of Munich, Germany.
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The efficacy of sulfadoxine/pyrimethamine (S/P) in treatment of uncomplicated falciparum malaria in Africa is increasingly compromised by development of resistance. The occurrence of active site mutations in the Plasmodium falciparum gene sequences coding for dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) is known to confer resistance to pyrimethamine and sulfadoxine. This study investigated the occurrence of these mutations in infected blood samples taken from Ugandan children before treatment with S/P and their relationship to parasite breakthrough by day 7. The results confirm the occurrence of mutations in DHFR and DHPS that were significantly selected under S/P pressure at day 7: a combination of alleles 51-isoleucine and 108-asparagine in DHFR, and 436-serine, 437-alanine, 540-lysine and 581-alanine in DHPS, appears to play a major role in the development of in vivo resistance in P. falciparum strains against S/P. Therefore, earlier results derived from isolates from hyperendemic areas in Tanzania were confirmed by this investigation.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1206 | 1076 | 39 |
| Full Text Views | 192 | 3 | 1 |
| PDF Downloads | 43 | 6 | 1 |