Author:
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1438 | 1253 | 47 |
| Full Text Views | 248 | 3 | 0 |
| PDF Downloads | 46 | 1 | 0 |
Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections.
D P Mason
D P Mason
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Search for other papers by D P Mason in
Current site
Google Scholar
PubMed
Search for other papers by D P Mason in
Current site
Google Scholar
PubMed
F E McKenzie
F E McKenzie
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Search for other papers by F E McKenzie in
Current site
Google Scholar
PubMed
Search for other papers by F E McKenzie in
Current site
Google Scholar
PubMed
We present a mathematical model of the blood-stage dynamics of mixed Plasmodium vivax-Plasmodium falciparum malaria infections in humans. The model reproduces features of such infections found in nature and suggests several phenomena that may merit clinical attention, including the potential recrudescence of a long-standing, low-level P. falciparum infection following a P. vivax infection or relapse and the capacity of an existing P. vivax infection to reduce the peak parasitemia of a P. falciparum superinfection. We simulate the administration of antimalarial drugs, and illustrate some potential complications in treating mixed-species malaria infections. Notably, our model indicates that when a mixed-species infection is misdiagnosed as a single-species P. vivax infection, treatment for P. vivax can lead to a surge in P. falciparum parasitemia.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1438 | 1253 | 47 |
| Full Text Views | 248 | 3 | 0 |
| PDF Downloads | 46 | 1 | 0 |