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Nitric oxide, malaria, and anemia: inverse relationship between nitric oxide production and hemoglobin concentration in asymptomatic, malaria-exposed children.
N M Anstey
N M Anstey
Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia.
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D L Granger
D L Granger
Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia.
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M Y Hassanali
M Y Hassanali
Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia.
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E D Mwaikambo
E D Mwaikambo
Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia.
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P E Duffy
P E Duffy
Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia.
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J B Weinberg
J B Weinberg
Tropical Medicine and International Health Unit, Menzies School of Health Research, Darwin, Northern Territory, Australia.
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The cause of the anemia associated with chronic, intermittent, asymptomatic, low-level parasitemia in children in malaria-endemic endemic areas is not well understood. Nitric oxide (NO) decreases erythropoiesis, and it is likely an important mediator of anemia of chronic disease. Production of NO is decreased in acute uncomplicated and cerebral malaria, but it is increased in asymptomatic Tanzanian children (with or without parasitemia). We hypothesized that chronic overproduction of NO in these asymptomatic children contributes to the anemia associated with subclinical/subpatent malaria. In 44 fasting, asymptomatic, malaria-exposed, Tanzanian children, NO production (measured using fasting urine NOx excretion) was inversely associated with hemoglobin concentration (P = 0.03, controlling for age and gender). Using multiple linear regression, hemoglobin concentration was negatively associated with parasitemia (P = 0.005). After controlling for age and parasitemia, NO was no longer an independent predictor of anemia. One of the mechanisms of parasite-related anemia in such children may be through the adverse hematologic effects of parasite-induced NO production.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 140 | 127 | 11 |
| Full Text Views | 260 | 0 | 0 |
| PDF Downloads | 90 | 0 | 0 |