Application of cardiac gated magnetic resonance imaging in murine Chagas' disease.

L A JelicksDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by L A Jelicks in
Current site
Google Scholar
PubMed
Close
,
J ShiraniDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by J Shirani in
Current site
Google Scholar
PubMed
Close
,
M WittnerDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by M Wittner in
Current site
Google Scholar
PubMed
Close
,
M ChandraDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by M Chandra in
Current site
Google Scholar
PubMed
Close
,
L M WeissDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by L M Weiss in
Current site
Google Scholar
PubMed
Close
,
S M FactorDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by S M Factor in
Current site
Google Scholar
PubMed
Close
,
I BekirovDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by I Bekirov in
Current site
Google Scholar
PubMed
Close
,
V L BraunsteinDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by V L Braunstein in
Current site
Google Scholar
PubMed
Close
,
J ChanDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by J Chan in
Current site
Google Scholar
PubMed
Close
,
H HuangDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by H Huang in
Current site
Google Scholar
PubMed
Close
, and
H B TanowitzDepartment of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Search for other papers by H B Tanowitz in
Current site
Google Scholar
PubMed
Close
Restricted access

To evaluate the role of gated cardiac magnetic imaging resonance (MRI) in Chagas' disease, we infected mice with Trypanosoma cruzi (Brazil strain). Two models were chosen for study, the CD1 and the inducible nitric oxide synthase knockout (NOS2-/-) mice. Infection of CD1 mice was associated with a significant increase in the right ventricular inner diameter (RVID) that was reversed in some mice by verapamil. Expression of cardiac NOS2 has been associated with myocardial dysfunction. Therefore, we evaluated chagasic cardiomyopathy in NOS2-/- and syngeneic wild type (WT) mice. Infected WT mice exhibited an increase in RVID in the acute phase (< 60 days postinfection) that was more marked during chronic infection (>100 days postinfection). Chronically infected NOS2-/- mice had an increase in RVID. The RVID in infected WT mice was greater than in NOS2-/- mice. These data demonstrate that MRI is a useful tool in the serial evaluation of the heart in murine Chagas' disease. In addition, it supports the notion that the NOS2-/-/NO pathway may contribute to the pathogenesis of murine chagasic cardiomyopathy.

Save