Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Collins WE, Jeffery GM, 1999. A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum: development of parasitologic and clinical immunity during primary infection. Am J Trop Med Hyg 61: (suppl):4–19.
-
2.
Young MD, Hardman NF, Burgess RW, Frohne WC, Sabrosky CW, 1948. The infectivity of native malarias in South Carolina to Anopheles quadrimaculatus. Am J Trop Med 28: 303–311.
-
3.
Jeffery GM, Eyles DE, Young MD, 1950. The comparative susceptibility of Anopheles quadrimaculatus and two strains of Anopheles albimanus to a Panama strain of Plasmodium falciparum. J Natl Malaria Soc 9: 349–355.
-
4.
Eyles DE, Young MD, 1950. The comparative susceptibility of Anopheles albimanus and Anopheles quadrimaculatus to a South Carolina strain of Plasmodium falciparum. J Infect Dis 87: 189–193.
-
5.
Young MD, Moore DV, 1961. Chloroquine resistance in Plasmodium falciparum. Am J Trop Med Hyg 10: 317–320.
-
6.
Young MD, Contacis PG, Stitcher JE, Millar JW, 1963. Drug resistance in Plasmodium falciparum from Thailand. Am J Trop Med Hyg 12: 305–314.
-
7.
Boyd MF, 1945. On difficulties arising in the experimental propagation of falciparum malaria. Am J Trop Med 25: 293–306.
-
8.
Earle WC, Perez M, 1932. Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17: 1124–1130.
-
9.
Mayne B, Young MD, 1941. The technique of induced malaria as used in the South Carolina State Hospital. Venereal Dis Information 22: 271–276.
-
10.
Collins WE, Collins GM, 1962. Methods and techniques for the handling of mosquitoes in human and animal malaria studies. Proceedings of the 49th Annual Meeting of the New Jersey Mosquito Extermination Association, 188–195.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 5850 | 5330 | 766 |
| Full Text Views | 3724 | 19 | 0 |
| PDF Downloads | 155 | 20 | 0 |
A Retrospective Examination of Secondary Sporozoite- and Trophozoite-Induced Infections with Plasmodium Falciparum: Development of Parasitologic and Clinical Immunity Following Secondary Infection
William E. Collins
William E. Collins
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
Search for other papers by William E. Collins in
Current site
Google Scholar
PubMed
Search for other papers by William E. Collins in
Current site
Google Scholar
PubMed
Geoffrey M. Jeffery
Geoffrey M. Jeffery
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
Search for other papers by Geoffrey M. Jeffery in
Current site
Google Scholar
PubMed
Search for other papers by Geoffrey M. Jeffery in
Current site
Google Scholar
PubMed
A retrospective study was made of clinical records to determine parasitemia and episodes of fever of 59 patients reinfected with Plasmodium falciparum for treatment of neurosyphilis, which was considered standard medical care at the time. Records were collected at the National Institutes of Health laboratories in Columbia, South Carolina and Milledgeville, Georgia during the period 1940 to 1963. Nineteen patients were infected via the bites of Anopheles albimanus, An. quadrimaculatus, or An. freeborni mosquitoes; the median prepatent period was 11.5 days. It was evident that clinical immunity, as measured by the frequency of fever, particularly high intensity fever (≥ 104°F), was increased following reinfection. The parasitologic immunity, as measured by the frequency of asexual parasite counts and gametocyte counts, was also evident. In general, in secondary infections with homologous and/or heterologous strains of P. falciparum, fever episodes ≥ 101¿ of and ≥ 104°F were reduced in number, parasitemia was reduced, and gametocyte production was reduced. However, despite long courses of parasitemia during their primary infections, most patients developed fever and, in some cases, high-density parasitemia and gametocytemia following reinfection. The intensity of the secondary response did not appear to be associated with the length of the previous course of parasitemia. In addition, current infection with heterologous strain parasites did not prevent the development of fever or higher density parasite counts following imposition of the new strain of parasite.
Author Notes
Authors' addresses: William E. Collins, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Mailstop F-12, 4770 Buford Highway, Atlanta, GA 30341-3724. Geoffrey M. Jeffery (Public Health S ervice, retired), 1093 Blackshear Drive, Decatur, Ga 30033.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Collins WE, Jeffery GM, 1999. A retrospective examination of sporozoite- and trophozoite-induced infections with Plasmodium falciparum: development of parasitologic and clinical immunity during primary infection. Am J Trop Med Hyg 61: (suppl):4–19.
-
2.
Young MD, Hardman NF, Burgess RW, Frohne WC, Sabrosky CW, 1948. The infectivity of native malarias in South Carolina to Anopheles quadrimaculatus. Am J Trop Med 28: 303–311.
-
3.
Jeffery GM, Eyles DE, Young MD, 1950. The comparative susceptibility of Anopheles quadrimaculatus and two strains of Anopheles albimanus to a Panama strain of Plasmodium falciparum. J Natl Malaria Soc 9: 349–355.
-
4.
Eyles DE, Young MD, 1950. The comparative susceptibility of Anopheles albimanus and Anopheles quadrimaculatus to a South Carolina strain of Plasmodium falciparum. J Infect Dis 87: 189–193.
-
5.
Young MD, Moore DV, 1961. Chloroquine resistance in Plasmodium falciparum. Am J Trop Med Hyg 10: 317–320.
-
6.
Young MD, Contacis PG, Stitcher JE, Millar JW, 1963. Drug resistance in Plasmodium falciparum from Thailand. Am J Trop Med Hyg 12: 305–314.
-
7.
Boyd MF, 1945. On difficulties arising in the experimental propagation of falciparum malaria. Am J Trop Med 25: 293–306.
-
8.
Earle WC, Perez M, 1932. Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17: 1124–1130.
-
9.
Mayne B, Young MD, 1941. The technique of induced malaria as used in the South Carolina State Hospital. Venereal Dis Information 22: 271–276.
-
10.
Collins WE, Collins GM, 1962. Methods and techniques for the handling of mosquitoes in human and animal malaria studies. Proceedings of the 49th Annual Meeting of the New Jersey Mosquito Extermination Association, 188–195.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 5850 | 5330 | 766 |
| Full Text Views | 3724 | 19 | 0 |
| PDF Downloads | 155 | 20 | 0 |