Treatment of Strongyloides Stercoralis Infection with Intravenous Gentian Violet

Donovan C. BrowneBrowne-McHardy Clinic, Department of Tropical Medicine and Public Health, Tulane University School of Medicine, 3636 St. Charles Avenue

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Peter G. ContacosBrowne-McHardy Clinic, Department of Tropical Medicine and Public Health, Tulane University School of Medicine, 3636 St. Charles Avenue

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George E. WelchBrowne-McHardy Clinic, Department of Tropical Medicine and Public Health, Tulane University School of Medicine, 3636 St. Charles Avenue

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Gordon McHardyBrowne-McHardy Clinic, Department of Tropical Medicine and Public Health, Tulane University School of Medicine, 3636 St. Charles Avenue

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The difficulty encountered in eradicating Strongyloides stercoralis infection in the human being is well recognized. Knowledge of its life cycle suggests some unusual problems, and clarification of some of the phases in its life cycle and immunology might point to more effective therapy. A discussion of these points however, is not within the province of this communication.

It was hoped, with the publication of Palmer (1950) on the use of intravenous gentian violet, that a simple and effective method of treatment had been evolved, for certainly gentian violet has been the most acceptable therapy to this date. It was with the purpose of confirming these observations of the efficacy of intravenous gentian violet that this study was undertaken.

Material. Fifteen patients with strongyloidiasis who could be hospitalized and controlled carefully on an ambulatory basis were selected for study. A 0.5 per cent solution of crystalline gentian violet was prepared in accordance with Palmer's technic, and 20 ml. of this solution were given intravenously daily.

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