Discussion of Dr. Elvio H. Sadun's Paper

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  • Department of Parasitology, School of Public Health, University of North Carolina, Chapel Hill, N. C.
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Dr. Sadun's studies on Opisthorchis viverrini have given for the first time a true idea of the importance of liver fluke infection in Thailand. They show that the disease caused by this parasite is one of the major health problems in that country, especially in the northeastern part among the Laos people. It may well be that more people suffer from severe liver fluke disease in the endemic areas of O. viverrini, which extend beyond the Mekong River into northwestern Viet Minh, than in all the endemic areas of Clonorchis sinensis. Extensive studies of the liver flukes of man during the last fifty years in Japan, Korea, China, Northern Indo-China and the U.S.S.R. have emphasized the difficulties of treatment, since the parasites in the small bile ducts of the liver become walled off and protected from drugs used in therapy by the extensive reactions of host tissues.