The Production of Antibodies in Rabbits Infected with Irradiated Trichinella Spiralis Larvae

E. H. Sadun Communicable Disease Center, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia

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L. Norman Communicable Disease Center, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia

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M. M. Brooke Communicable Disease Center, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia

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Summary

Rabbits that received single inoculations by mouth of irradiated larvae of Trichinella spiralis failed to produce antibodies in sufficient amounts to be detected by the flocculation and complement-fixation tests. Multiple feedings with irradiated larvae produced a positive serology at low titers and of brief duration. Extra-intestinal larval inoculations stimulated the production of antibodies in relatively high titers. A re-evaluation of the significance of positive serology in trichinosis might become necessary if the recommendation of commercially irradiating pork as a means of protecting human beings from trichinosis should be widely adopted.

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