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Anti-leishmanial IgE antibodies: a marker of active disease in visceral leishmaniasis.
A M Atta
A M Atta
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
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D'Oliveira
D'Oliveira
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
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J Correa
J Correa
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
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M L Atta
M L Atta
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
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R P Almeida
R P Almeida
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
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E M Carvalho
E M Carvalho
Departamento de Análises Clinicas e Toxicológicas, Faculdade de Farmácia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil.
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Visceral leishmaniasis (VL) is characterized by a depression of the T helper cell type 1 immune response. Although mRNA expression for interleukin-4 (IL-4) is observed, evidence of the role of this cytokine in the pathogenesis of VL has been lacking. Since IL-4 is involved in IgE synthesis, we measured the total IgE and Leishmania antigen-specific IgE antibody levels in sera from patients with VL. Specific IgE antibodies detected by an ELISA technique after absorbing the sera with purified sheep IgG anti-human IgG were found in all 23 patients with VL and were not detected in subjects with subclinical Leishmania chagasi infection (n = 10), Chagas' disease (n = 10), atopic patients (n = 10), and healthy controls (n = 10). Levels of Leishmania-specific IgE (optical density values) before and after treatment were 0.100 +/- 0.03 (mean +/- SD) and 0.028 +/- 0.002, respectively (P < 0.05). These results indicate that a specific IgE response is useful in the diagnosis of active disease and to evaluate response to treatment.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 423 | 85 | 6 |
| Full Text Views | 9 | 0 | 0 |
| PDF Downloads | 7 | 0 | 0 |