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Salvador II strain of Plasmodium vivax in Aotus monkeys and mosquitoes for transmission-blocking vaccine trials.
W E Collins
W E Collins
Division of Parasitic Diseases and Animal Resources Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341-3724, USA.
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B B Richardson
B B Richardson
Division of Parasitic Diseases and Animal Resources Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341-3724, USA.
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C L Morris
C L Morris
Division of Parasitic Diseases and Animal Resources Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341-3724, USA.
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J S Sullivan
J S Sullivan
Division of Parasitic Diseases and Animal Resources Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341-3724, USA.
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G G Galland
G G Galland
Division of Parasitic Diseases and Animal Resources Branch, Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia 30341-3724, USA.
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Infections with the Salvador II strain of Plasmodium vivax in Aotus lemurinus griseimambra monkeys were fed upon by Anopheles freeborni mosquitoes. Periods of mosquito infectivity were determined to establish a model system for the testing of transmission-blocking vaccines. The highest levels of mosquito infection were associated with the ascending asexual parasitemia after reaching 1,000/microl, and before the peak asexual parasite count. Sporozoite-induced infections were more infectious than were trophozoite-induced infections. Secondary episodes of parasitemia were also infectious, indicating the lack of development of naturally developing transmission-blocking immunity to this strain of P. vivax in splenectomized Aotus monkeys following single infections.
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| Past two years | Past Year | Past 30 Days | |
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