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Treatment of chronic Chagas' disease with itraconazole and allopurinol.
W Apt
W Apt
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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X Aguilera
X Aguilera
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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A Arribada
A Arribada
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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C Pérez
C Pérez
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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C Miranda
C Miranda
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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G Sánchez
G Sánchez
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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I Zulantay
I Zulantay
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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P Cortés
P Cortés
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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J Rodriguez
J Rodriguez
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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D Juri
D Juri
Department of Parasitology, Faculty of Medicine, University of Chile, Santiago.
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Four hundred four patients with chronic Chagas' disease were treated with itraconazole (6 mg/kg of body weight/day for 120 days), allopurinol (8.5 mg/kg of body weight/day for 60 days), or with a placebo of pure starch. Patients were monitored over a period of four years by clinical examination, serology, xenodiagnosis, hemoculture, and electrocardiogram. Drug tolerance was good, with only four treatments discontinued due to side effects that subsided after suspension of treatment. Parasitologic cure was evident in 44% of the those treated with allopurinol and 53% of those treated with itraconazole, and the electrocardiographic evaluation showed normalization in 36.5% and 48.2%, respectively, of patients with chronic or recent cardiopathy.
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| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 912 | 575 | 220 |
| Full Text Views | 16 | 7 | 0 |
| PDF Downloads | 24 | 13 | 0 |