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Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity.
S Nazario
S Nazario
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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S Das
S Das
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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A M de Silva
A M de Silva
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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K Deponte
K Deponte
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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N Marcantonio
N Marcantonio
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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J F Anderson
J F Anderson
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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D Fish
D Fish
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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E Fikrig
E Fikrig
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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F S Kantor
F S Kantor
Department of Internal Medicine, Yale University, New Haven, Connecticut, USA.
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We examined the effect of repeated infestation of guinea pigs with Ixodes scapularis on the capacity of ticks to transmit Borrelia burgdorferi infection. Repeated challenges with nymphs or larvae lead to a reduction in duration of nymphal tick attachment and weight of recovered ticks consistent with the development of tick immunity. Only one of 18 I. scapularis-immune guinea pigs challenged with B. burgdorferi-infected nymphal ticks became infected, whereas 10 of 18 naive guinea pigs similarly challenged became infected. We conclude that tick immunity interferes with borrelial transmission.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 693 | 392 | 17 |
| Full Text Views | 37 | 22 | 3 |
| PDF Downloads | 41 | 28 | 5 |