Author:
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 120 | 58 | 6 |
| Full Text Views | 9 | 0 | 0 |
| PDF Downloads | 9 | 0 | 0 |
In vitro activity of artemether against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial drugs.
B Pradines
B Pradines
Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Search for other papers by B Pradines in
Current site
Google Scholar
PubMed
Search for other papers by B Pradines in
Current site
Google Scholar
PubMed
C Rogier
C Rogier
Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Search for other papers by C Rogier in
Current site
Google Scholar
PubMed
Search for other papers by C Rogier in
Current site
Google Scholar
PubMed
T Fusai
T Fusai
Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Search for other papers by T Fusai in
Current site
Google Scholar
PubMed
Search for other papers by T Fusai in
Current site
Google Scholar
PubMed
A Tall
A Tall
Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Search for other papers by A Tall in
Current site
Google Scholar
PubMed
Search for other papers by A Tall in
Current site
Google Scholar
PubMed
J F Trape
J F Trape
Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Search for other papers by J F Trape in
Current site
Google Scholar
PubMed
Search for other papers by J F Trape in
Current site
Google Scholar
PubMed
J C Doury
J C Doury
Unite de Parasitologie, Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Search for other papers by J C Doury in
Current site
Google Scholar
PubMed
Search for other papers by J C Doury in
Current site
Google Scholar
PubMed
The in vitro activity of artemether against 56 African isolates of Plasmodium falciparum from Senegal was evaluated using an isotope-based drug susceptibility semi-microtest. The 50% inhibitory concentration (IC50) values for artemether were in a narrow range from 0.8 to 15.2 nM (mean IC50 = 3.43 nM) and the 95% confidence interval (CI) was 2.50-4.36 nM. Artemether was equally effective on chloroquine-sensitive and chloroquine-resistant isolates (mean IC50 = 346 nM, 95% CI = 2.08-4.84 nM versus mean IC50 = 2.80 nM, 95% CI = 2.00-3.60 nM). There was a significant positive correlation between responses to artemether and mefloquine (r2 = 0.36, P < 0.001), artemether and quinine (r2 = 0.085, P < 0.05), artemether and halofantrine (r2 = 0.075, P < 0.05), quinine and mefloquine (r2 = 0.205, P < 0.01), quinine and halofantrine (r2 = 0.124, P < 0.05), and mefloquine and halofantrine (r2 = 0.801, P < 0.001). A positive correlation between these drugs suggests in vitro cross-resistance or at least in vitro cross-susceptibility.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 120 | 58 | 6 |
| Full Text Views | 9 | 0 | 0 |
| PDF Downloads | 9 | 0 | 0 |