Involvement of Cytokines in the Histopathology of Cerebral Malaria

Rachanee Udomsangpetch Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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Songpol Chivapat Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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Parnpen Viriyavejakul Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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Mario Riganti Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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Polrat Wilairatana Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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Emsri Pongponratn Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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Sornchai Looareesuwan Department of Pathobiology, Faculty of Science, Department of Tropical Pathology, Faculty of Tropical Medicine, and Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.1997.57.501
Volume/Issue:
Volume 57: Issue 5
Page(s):
501–506
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Histopathologic and immunohistologic studies were performed in two cases of fatal cerebral malaria. On admission, both patients were in unarousable coma with hyperparasitemia. Examination of the tissue sections from various organs showed parasite sequestration in both cases with more extensive area of sequestration in case 1 than in case 2. A panel of monoclonal antibodies against cytokines applied to these tissues clearly detected tumor necrosis factor-alpha (TNFα), interferon-gamma (IFNγ), interleukin-1B (IL-1β), and IL-10 in the tissues from brain and liver of case 1. A different cytokine profile, IL-4 and IL-10, was found in the brain tissues of case 2; no TNFα nor IFNγ was detected. There was no cytokine detected in the tissues of other organs in either case. Results of the study suggest that histopathology in the brain of fatal cerebral malaria may be associated with focal accumulation of cytokines. Additionally, the type of cytokines produced locally in a particular tissue during malaria infection may be regulated by the degree of regional parasite sequestration.

Author Notes

Copyright:
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene 1997
Published Online:
Nov 1997
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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