Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 296 95 2
Full Text Views 17 7 0
PDF Downloads 14 7 0
 
 
 
 
 
 
 
 
 
 
 

Immunogenicity of Recombinant Hepatitis B Vaccine Among Infants of Mothers with Active Schistosomiasis

Samir BassilyU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Samir Bassily in
Current site
Google Scholar
PubMedClose
,
Amira KotkatU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Amira Kotkat in
Current site
Google Scholar
PubMedClose
,
Kenneth C. HyamsU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Kenneth C. Hyams in
Current site
Google Scholar
PubMedClose
,
Fouad G. YoussefU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Fouad G. Youssef in
Current site
Google Scholar
PubMedClose
,
Nabil A. El-MasryU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Nabil A. El-Masry in
Current site
Google Scholar
PubMedClose
,
Ray ArthurU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Ray Arthur in
Current site
Google Scholar
PubMedClose
,
Imam Z. ImamU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Imam Z. Imam in
Current site
Google Scholar
PubMedClose
, and
Forrest M. BrownU.S. Naval Medical Research Unit No. 3, High Institute of Public Health, U.S. Naval Medical Research Institute, Department of Molecular Microbiology and Immunology, Johns Hopkins University, School of Hygiene and Public Health, Cairo, Egypt

Search for other papers by Forrest M. Brown in
Current site
Google Scholar
PubMedClose
View More View Less
DOI:
https://doi.org/10.4269/ajtmh.1997.57.197
Volume/Issue:
Volume 57: Issue 2
Page(s):
197–199
Restricted access
Get Permissions

A study of the immunogenicity of a recombinant hepatitis B vaccine was conducted among 385 Egyptian infants, 191 (49.6%) of whom were born to mothers with moderately active Schistosoma mansoni infection (mean egg count = 224 eggs/g of feces). All mothers were seronegative for hepatitis B surface antigen (HBsAg) and hepatitis B e antigen. Infants were vaccinated with a 2.5-µg dose of this vaccine, given along with diphtheria, tetanus, and pertussis (DTP) vaccine, at the ages of two, four, and six months. Serum samples taken from each infant at nine months of age were tested for HBsAg, antibody to hepatitis B core antigen, and quantitatively for antibody to hepatitis B surface antigen (anti-HBs). There was no significant difference (P = 0.1) between anti-HBs titers in infants of S. mansoni-infected mothers (mean = 539 mIU/ml) and in infants of noninfected mothers (mean = 377 mIU/ml). This study shows that there was no apparent effect of maternal schistosomiasis infection on the immune response of these infants to vaccination.
Copyright:
Copyright © 1997, by The American Society of Tropical Medicine and Hygiene 1997
Published Online:
Aug 1997
Save