Human T Cell Lymphotropic Virus Type-1—Associated Myelopathy/Tropical Spastic Paraparesis in Sao Paulo, Brazil: Association with Blood Transfusion

Renan B. Domingues Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Renan B. Domingues in
Current site
Google Scholar
PubMed
Close
,
Marcelo R. Muniz Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Marcelo R. Muniz in
Current site
Google Scholar
PubMed
Close
,
Maria Lucia G. Jorge Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Maria Lucia G. Jorge in
Current site
Google Scholar
PubMed
Close
,
Matthew S. Mayo Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Matthew S. Mayo in
Current site
Google Scholar
PubMed
Close
,
Amadeu Saez-Alquezar Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Amadeu Saez-Alquezar in
Current site
Google Scholar
PubMed
Close
,
Dalton F. Chamone Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Dalton F. Chamone in
Current site
Google Scholar
PubMed
Close
,
Milberto Scaff Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Milberto Scaff in
Current site
Google Scholar
PubMed
Close
, and
Paulo E. Marchiori Department of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

Search for other papers by Paulo E. Marchiori in
Current site
Google Scholar
PubMed
Close
Restricted access

Human T cell lymphotropic virus type-1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) has been epidemiologically linked to prior blood transfusion. The prevalence of transfusion as a risk factor for infection varies among endemic areas. Here we report the relative frequency of reported history of blood transfusion among 52 patients evaluated in Sao Paulo, Brazil. A patient reported history of blood transfusion prior to the onset of symptoms, found in 15 (28.8%) of the patients, was the most important risk factor identified in this group of patients when compared with a history of sexually transmitted diseases, homo/bisexuality, sexual promiscuity (three or more sexual partners a year), and intravenous drug use. The mean time between reported transfusions and the onset of symptoms was longer than previously reported. There was no trend toward a more severe evolution to motor inability among the HAM/TSP patients with a history of previous transfusion.

Author Notes

Save