Human T Cell Lymphotropic Virus Type-1—Associated Myelopathy/Tropical Spastic Paraparesis in Sao Paulo, Brazil: Association with Blood Transfusion

Renan B. DominguesDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Marcelo R. MunizDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Maria Lucia G. JorgeDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Matthew S. MayoDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Amadeu Saez-AlquezarDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Dalton F. ChamoneDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Milberto ScaffDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Paulo E. MarchioriDepartment of Neurology, University of Sao Paulo, School of Medicine, Fundacao Pro-Sangue/Hemocentro de Sao Paulo, Biostatistics Unit, Comprehensive Cancer Center, University of Alabama at Birmingham, Sao Paulo, Brazil

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Human T cell lymphotropic virus type-1 (HTLV-1) associated myelopathy/tropical spastic paraparesis (HAM/TSP) has been epidemiologically linked to prior blood transfusion. The prevalence of transfusion as a risk factor for infection varies among endemic areas. Here we report the relative frequency of reported history of blood transfusion among 52 patients evaluated in Sao Paulo, Brazil. A patient reported history of blood transfusion prior to the onset of symptoms, found in 15 (28.8%) of the patients, was the most important risk factor identified in this group of patients when compared with a history of sexually transmitted diseases, homo/bisexuality, sexual promiscuity (three or more sexual partners a year), and intravenous drug use. The mean time between reported transfusions and the onset of symptoms was longer than previously reported. There was no trend toward a more severe evolution to motor inability among the HAM/TSP patients with a history of previous transfusion.

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