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The Pharmacokinetics of a Single Dose of Artemisinin in Patients with Uncomplicated Falciparum Malaria
Peter J. De Vries
Peter J. De Vries
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Tran Khac Dien
Tran Khac Dien
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Nguyen Xuan Khanh
Nguyen Xuan Khanh
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Le Nguyen Binh
Le Nguyen Binh
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Pham Thi Yen
Pham Thi Yen
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Dao Dinh Duc
Dao Dinh Duc
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Chris J. Van Boxtel
Chris J. Van Boxtel
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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Piet A. Kager
Piet A. Kager
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, University of Amsterdam, Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Institute of Malariology, Parasitology and Entomology, Amsterdam, The Netherlands
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The pharmacokinetics of artemisinin was studied in 11 Vietnamese patients with uncomplicated falciparum malaria after a single 500 mg oral dose. Curative treatment with mefloquine (15 mg/kg) was provided 24 hr after the artemisinin dose. Artemisinin concentrations were measured by high-performance liquid chromatography with electrochemical detection. The following pharmacokinetic results were found (all mean ± SD): calculated volume of distribution/bioavailability = 22.8 ± 16.6 L.kg-1, mean absorption time = 1.16 ± 0.92 hr, calculated maximum concentration = 364 ± 250 µg.L-1 occurring at 2.88 ± 1.71 hr after drug intake, and an elimination half-life of 2.72 ± 1.76 hr. Bioavailability was low. These results do not differ from results in healthy subjects. Parasites disappeared rapidly, with a mean parasite clearance time of 36 hr. No relationship was found between pharmacokinetics and the parasite elimination rate. Tolerance to the single dose of artemisinin was good. No adverse effects were detected. In conclusion, pharmacokinetics of a single dose of artemisinin for uncomplicated falciparum malaria is not different from findings in healthy subjects. A single dose of 500 mg of artemisinin is effective in reducing parasitemia in nonsevere falciparum malaria and is well-tolerated.
Author Notes
In collaboration with the following members of the Bach Mai-Amsterdam Research Group on Artemisinin: Bob van de Berg (Amsterdam, Department of Clinical Pharmacology and Pharmacotherapy), Jan Butter (Amsterdam, Department of Clinical Pharmacology and Pharmacotherapy), Bui Hien (Hanoi, Institute for Clinical Research in Tropical Medicine), Richard P. Koopmans (Amsterdam, Department of Clinical Pharmacology and Pharmacotherapy), Els Portier (Amsterdam, Department of Clinical Pharmacology and Pharmacotherapy), Pham Song (Hanoi, Institute for Clinical Research in Tropical Medicine), and Dang Cam Thach (Hanoi, Institute of Malariology, Parasitology, and Entomology).
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1606 | 1196 | 36 |
| Full Text Views | 23 | 6 | 3 |
| PDF Downloads | 29 | 5 | 2 |