Protection of Mice from Fatal Bubonic and Pneumonic Plague by Passive Immunization with Monoclonal Antibodies against the F1 Protein of Yersinia pestis

George W. Anderson Jr U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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Patricia L. Worsham U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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Christopher R. Bolt U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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Gerard P. Andrews U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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Susan L. Welkos U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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Arthur M. Friedlander U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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James P. Burans U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Naval Medical Research Institute, Frederick, Maryland

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Monoclonal antibodies (MAbs) to the fraction 1 (F1) protein of Yersinia pestis protected mice against fatal pneumonic as well as bubonic plague from wild-type F1+ organisms. The rare isolation of a virulent F1- isolate from surviving animals supports earlier studies suggesting that improved vaccines should consist of immunogens to protect against F1 - variants. The high degree of protection with IgG MAb suggests that secretory IgA is not required for protection from pneumonic plague.

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