Patterns of Association with Host and Habitat: Antibody Reactive with Sin Nombre Virus in Small Mammals in the Major Biotic Communities of the Southwestern United States

James N. MillsDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by James N. Mills in
Current site
Google Scholar
PubMed
Close
,
Thomas G. KsiazekDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Thomas G. Ksiazek in
Current site
Google Scholar
PubMed
Close
,
Barbara A. EllisDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Barbara A. Ellis in
Current site
Google Scholar
PubMed
Close
,
Pierre E. RollinDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Pierre E. Rollin in
Current site
Google Scholar
PubMed
Close
,
Stuart T. NicholDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Stuart T. Nichol in
Current site
Google Scholar
PubMed
Close
,
Terry L. YatesDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Terry L. Yates in
Current site
Google Scholar
PubMed
Close
,
William L. GannonDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by William L. Gannon in
Current site
Google Scholar
PubMed
Close
,
Craig E. LevyDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Craig E. Levy in
Current site
Google Scholar
PubMed
Close
,
David M. EngelthalerDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by David M. Engelthaler in
Current site
Google Scholar
PubMed
Close
,
Ted DavisDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Ted Davis in
Current site
Google Scholar
PubMed
Close
,
Dale T. TandaDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Dale T. Tanda in
Current site
Google Scholar
PubMed
Close
,
J. Wyatt FramptonDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by J. Wyatt Frampton in
Current site
Google Scholar
PubMed
Close
,
Craig R. NicholsDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by Craig R. Nichols in
Current site
Google Scholar
PubMed
Close
,
C. J. PetersDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by C. J. Peters in
Current site
Google Scholar
PubMed
Close
, and
James E. ChildsDivision of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Public Health Service, Department of Molecular Microbiology and Immunology, Johns Hopkins University, Department of Biology, University of New Mexico, Vector-Borne and Zoonotic Disease Section, Arizona Department of Health Services, Colorado Department of Public Health and Environment, Bureau of Epidemiology, Utah Department of Health, Atlanta, Georgia

Search for other papers by James E. Childs in
Current site
Google Scholar
PubMed
Close
Restricted access

The distribution and prevalence of antibody reactive with Sin Nombre virus were determined in mammals in biotic communities of the southwestern United States. Small mammals (n = 3,069) of 69 species were trapped in nine communities from lower Sonoran desert to alpine tundra. Antibody was found in rodents from all communities (overall prevalence = 6.3%); prevalence was lowest at the altitudinal and climatic extremes (0.4% in desert and 2.0% in alpine tundra). Antibody occurred in 11% of 928 deer mice, 20% of 355 brush mice, 23% of 35 western harvest mice, and 12% of 24 Mexican voles. No infected deer mice were found in desert habitat; prevalence varied from 4% in chaparral to 17% in pinyon-juniper. Brush mice were frequently infected in chaparral and montane forest (25%). Seropositivity was higher in males and in heavier animals, suggesting horizontal transmission among adult males. Decreasing prevalence with age among the youngest deer mice suggests that infected dams confer passive immunity to pups.

Save