Protective Immunity Induced in Squirrel Monkeys with a Multiple Antigen Construct against the Circumsporozoite Protein of Plasmodium vivax

William E. Collins Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Joann S. Sullivan Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Carla L. Morris Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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G. Gale Galland Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Danny L. Jue Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Sunan Fang Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Robert Wohlhueter Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Robb C. Reed Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Chunfu Yang Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Robert L. Hunter Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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Altaf A. Lal Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia

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DOI:
https://doi.org/10.4269/ajtmh.1997.56.200
Volume/Issue:
Volume 56: Issue 2
Page(s):
200–210
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Saimiri boliviensis monkeys were immunized with a multiple antigen construct [(PvCS)2]2(P2)2 directed against the circumsporozoite protein of Plasmodium vivax or a combination of the multiple antigen construct with nonionic copolymer P1005, with P1005 and lipopolysaccharide, with muramyl tripeptide Mf-75, or with alum. Following intravenous challenge with 10,000 sporozoites of the Salvador I strain of P. vivax, 11 of the 26 monkeys were protected against patent parasitemia. Ten additional animals were partially protected. Following rechallenge of the 26 monkeys with 30,000 sporozoites of the homologous strain of parasite, four monkeys were totally protected and nine animals were partially protected.

Author Notes

Copyright:
Copyright © 1997 by The American Society of Tropical Medicine and Hygiene 1997
Published Online:
Feb 1997
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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