Short Report: Gametocytes, Chloroquine Pressure, and the Relative Parasite Survival Advantage of Resistant Strains of Falciparum Malaria in West Africa

Vincent Robert Institut Francais de Recherche Scientifique pour le Developpement en Cooperation (ORSTOM), Laboratoire de Paludologie, Dakar, Senegal

Search for other papers by Vincent Robert in
Current site
Google Scholar
PubMed Close
,
Jean-Francois Molez Institut Francais de Recherche Scientifique pour le Developpement en Cooperation (ORSTOM), Laboratoire de Paludologie, Dakar, Senegal

Search for other papers by Jean-Francois Molez in
Current site
Google Scholar
PubMed Close
, and
Jean-Francois Trape Institut Francais de Recherche Scientifique pour le Developpement en Cooperation (ORSTOM), Laboratoire de Paludologie, Dakar, Senegal

Search for other papers by Jean-Francois Trape in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1996.55.350
Volume/Issue:
Volume 55: Issue 3
Page(s):
350–351
Restricted access
Get Permissions

Patients with Plasmodium falciparum infections were selected with an in vivo chloroquine sensitivity assay. Fourteen days after treatment, the gametocytes were studied in relation to asexual parasite responses classified as drug-sensitive or showing RI or RII resistance. Gametocyte prevalence and density appeared significantly higher in RII than RI strains and higher in RI than in sensitive strains. This finding on gametocyte variation in vivo may explain why the RII type of chloroquine resistance has became more prevalent than RI everywhere in tropical Africa in the short time since its emergence. The biological and epidemiologic advantage of chloroquine-resistant malaria mediated through gametocytes is discussed in the context of the present drug pressure in Africa.

Author Notes

Copyright:
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene 1996
Published Online:
Sep 1996
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637

Expert Committee on Hepatitis

First Report. World Health Organization Technical Report Series No. 62 (Available also in French). 26 pp. Geneva, W.H.O., Palais des Nations. March, 1953. Price 1/6, $0.20, Fr. fr. 65.-; Sw. fr. 0.80

Past two years Past Year Past 30 Days
Abstract Views 2107 1753 448
Full Text Views 13 3 2
PDF Downloads 9 2 0
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save