A Correlation of the Sequestration Rate of Plasmodium coatneyi-Infected Erythrocytes in Cerebral and Subcutaneous Tissues of a Rhesus Monkey

Yamaji NakanoInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Hisashi FujiokaInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Kiet Dan LucInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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John R. RabbegeInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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G. Daniel ToddInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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William E. CollinsInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Masamichi AikawaInstitute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Parasitized red blood cells (PRBCs) were sequestered in microvessels of cerebral and subcutaneous tissues of a rhesus monkey infected with Plasmodium coatneyi. A similar sequestration rate (approximately 80%) was observed in both cerebral and subcutaneous microvessels. Electron microscopy showed knobs of the sequestrated PRBCs cytoadhered to endothelial cells. These results are consistent with the finding of PRBC sequestration in subcutaneous tissues in a comatose patient with cerebral malaria. Biopsy specimens of subcutaneous tissue may be useful as indicators of PRBC sequestration in the brain of cerebral malaria patients.

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