A Correlation of the Sequestration Rate of Plasmodium coatneyi-Infected Erythrocytes in Cerebral and Subcutaneous Tissues of a Rhesus Monkey

Yamaji Nakano Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Hisashi Fujioka Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Kiet Dan Luc Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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John R. Rabbege Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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G. Daniel Todd Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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William E. Collins Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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Masamichi Aikawa Institute of Pathology, Case Western Reserve University, Division of Parasitic Diseases, Centers for Disease Control and Prevention, Institute of Medical Sciences, Tokai University, Cleveland, Ohio, Georgia

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DOI:
https://doi.org/10.4269/ajtmh.1996.55.311
Volume/Issue:
Volume 55: Issue 3
Page(s):
311–314
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Parasitized red blood cells (PRBCs) were sequestered in microvessels of cerebral and subcutaneous tissues of a rhesus monkey infected with Plasmodium coatneyi. A similar sequestration rate (approximately 80%) was observed in both cerebral and subcutaneous microvessels. Electron microscopy showed knobs of the sequestrated PRBCs cytoadhered to endothelial cells. These results are consistent with the finding of PRBC sequestration in subcutaneous tissues in a comatose patient with cerebral malaria. Biopsy specimens of subcutaneous tissue may be useful as indicators of PRBC sequestration in the brain of cerebral malaria patients.

Author Notes

Copyright:
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene 1996
Published Online:
Sep 1996
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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