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Field Detection of Sulfonamides in Urine: The Development of a New and Sensitive Test
Dwight L. Mount
Dwight L. Mount
Entomology Branch, and Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clinical Research Centre, Kenya Medical Research Institute, Atlanta, Georgia, Kenya
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Michael D. Green
Michael D. Green
Entomology Branch, and Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clinical Research Centre, Kenya Medical Research Institute, Atlanta, Georgia, Kenya
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Jane R. Zucker
Jane R. Zucker
Entomology Branch, and Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clinical Research Centre, Kenya Medical Research Institute, Atlanta, Georgia, Kenya
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J. Ben O. Were
J. Ben O. Were
Entomology Branch, and Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clinical Research Centre, Kenya Medical Research Institute, Atlanta, Georgia, Kenya
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G. Daniel Todd
G. Daniel Todd
Entomology Branch, and Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Clinical Research Centre, Kenya Medical Research Institute, Atlanta, Georgia, Kenya
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A new, field-adapted, colorimetric method for detecting sulfonamide drugs in urine is described. The method uses the color reagent, p-dimethylaminocinnamaldehyde, and has a detection limit of about 1 µg/ml. Analysis of 35 samples collected in the field, comparing results obtained with the colorimetric field test with those obtained using high-performance liquid chromatography, indicated a calculated sensitivity value of 94% and a specificity value of 94% for the test to detect the presence of sulfonamides. The field test can be modified to allow quantitation of sulfonamides in urine in field situations, using a hand-held, portable photometer for measuring the absorbance of test solutions. For this test, calculated coefficients of variation for day to day reproducibility were ≤ 5% at sulfonamide concentrations ≥ 3 µg/ml. This new test for detecting the presence of sulfonamides in urine is more sensitive and reliable than the presently used Bratton-Marshall test.
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| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 631 | 281 | 109 |
| Full Text Views | 16 | 2 | 0 |
| PDF Downloads | 13 | 3 | 0 |