The Effects of Pyronaridine on the Morphology of Plasmodium falciparum in Aotus Trivirgatus

Satoru Kawai Department of Parasitology, Gunma University School of Medicine, Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Maebashi, Japan

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Shigeyuki Kano Department of Parasitology, Gunma University School of Medicine, Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Maebashi, Japan

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Chen Chang Department of Parasitology, Gunma University School of Medicine, Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Maebashi, Japan

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Mamoru Suzuki Department of Parasitology, Gunma University School of Medicine, Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Maebashi, Japan

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DOI:
https://doi.org/10.4269/ajtmh.1996.55.223
Volume/Issue:
Volume 55: Issue 2
Page(s):
223–229
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The effects of pyronaridine on the morphology of Plasmodium falciparum were studied in an infected owl monkey (Aotus trivirgatus) that was severely ill with a parasitemia of 28%. Thirty minutes after pyronaridine administration, distinct morphologic changes were already present in late trophozoites and schizonts. Ultrastructural observations revealed that the earliest and most distinct changes induced by pyronaridine occurred in food vacuoles. The most striking change in food vacuoles was the appearance of undigested endocytic vesicles surrounded by a single membrane in the vacuolar space. These findings suggest that vacuolar degradation is inhibited by pyronaridine, and that undigested endocytic vesicles accumulate inside parasite food vacuoles impairing hemoglobin degeneration. Thus, pyronaridine appears to interfere with the parasitic digestive system.
Copyright:
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene 1996
Published Online:
Aug 1996
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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