Effects of High-Dose Oral Vitamin A on Diarrheal Episodes among Children with Persistent Diarrhea in a Northeast Brazilian Community

Bryan L. WalserDivision of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Clinical Research Unit, Federal University of Ceara, Charlottesville, Virginia, Brazil

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Aldo A. M. LimaDivision of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Clinical Research Unit, Federal University of Ceara, Charlottesville, Virginia, Brazil

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Richard L. GuerrantDivision of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Clinical Research Unit, Federal University of Ceara, Charlottesville, Virginia, Brazil

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The mean ± SEM duration of diarrheal episodes decreased from 7.1 ± 2.2 days to 4.3 ± 0.9 days (P < 0.05) while the incidence of diarrheal episodes remained steady (2.2 ± 0.3 versus 2.4 ± 0.5 episodes; P = not significant) between two three-month periods before and after the oral administration of a single large age-adjusted dose of vitamin A among children at historical risk for persistent diarrhea in an impoverished Brazilian community.

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