Effects of High-Dose Oral Vitamin A on Diarrheal Episodes among Children with Persistent Diarrhea in a Northeast Brazilian Community

Bryan L. Walser Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Clinical Research Unit, Federal University of Ceara, Charlottesville, Virginia, Brazil

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Aldo A. M. Lima Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Clinical Research Unit, Federal University of Ceara, Charlottesville, Virginia, Brazil

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Richard L. Guerrant Division of Geographic and International Medicine, Department of Medicine, University of Virginia School of Medicine, Clinical Research Unit, Federal University of Ceara, Charlottesville, Virginia, Brazil

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The mean ± SEM duration of diarrheal episodes decreased from 7.1 ± 2.2 days to 4.3 ± 0.9 days (P < 0.05) while the incidence of diarrheal episodes remained steady (2.2 ± 0.3 versus 2.4 ± 0.5 episodes; P = not significant) between two three-month periods before and after the oral administration of a single large age-adjusted dose of vitamin A among children at historical risk for persistent diarrhea in an impoverished Brazilian community.

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