The Santa Lucia Strain of Plasmodium falciparum as a Model for Vaccine Studies. II. Development of Aotus vociferans as a Model for Testing Transmission-Blocking Vaccines

William E. Collins Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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G. Gale Galland Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Joann S. Sullivan Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Carla L. Morris Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Bettye B. Richardson Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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DOI:
https://doi.org/10.4269/ajtmh.1996.54.380
Volume/Issue:
Volume 54: Issue 4
Page(s):
380–385
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The Santa Lucia strain of Plasmodium falciparum and the Aotus vociferans monkey were studied as models for the testing of transmission-blocking vaccines. Virulence developed early in the passage history. Despite the use of only small quantities of chlorguanide and/or quinine to control infection coupled with the use of small inocula and delays in splenectomy, mosquito infection was markedly reduced from that seen during primary passage to this species of Aotus. It appears that the model may be most useful during its initial passage from the primary species, Aotus lemurinus griseimembra.

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Copyright:
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene 1996
Published Online:
Apr 1996
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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