The Santa Lucia Strain of Plasmodium falciparum as a Model for Vaccine Studies. I. Development in Aotus lemurinus griseimembra Monkeys

William E. Collins Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Search for other papers by William E. Collins in
Current site
Google Scholar
PubMed Close
,
G. Gale Galland Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Search for other papers by G. Gale Galland in
Current site
Google Scholar
PubMed Close
,
Joann S. Sullivan Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Search for other papers by Joann S. Sullivan in
Current site
Google Scholar
PubMed Close
,
Carla L. Morris Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Search for other papers by Carla L. Morris in
Current site
Google Scholar
PubMed Close
,
Bettye B. Richardson Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Search for other papers by Bettye B. Richardson in
Current site
Google Scholar
PubMed Close
, and
Jacquelin M. Roberts Division of Parasitic Diseases and Scientific Resources Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Search for other papers by Jacquelin M. Roberts in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1996.54.372
Volume/Issue:
Volume 54: Issue 4
Page(s):
372–379
Restricted access
Get Permissions

The Santa Lucia strain of Plasmodium falciparum and the Aotus lemurinus griseimembra monkey are proposed as models for the testing of sporozoite vaccines and transmission-blocking vaccines. Approximately 85% of splenectomized monkeys were infected when fed upon by 10 or more heavily infected Anopheles freeborni mosquitoes. Sporozoite-induced infections in monkeys with or without previous infection with P. vivax readily infected mosquitoes, thus making them candidates for testing transmission-blocking vaccines.

Author Notes

Copyright:
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene 1996
Published Online:
Apr 1996
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 1078 806 14
Full Text Views 20 4 1
PDF Downloads 19 7 1
 
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save