In Vitro Antimalarial Activity of Vegetal Extracts Used in West African Traditional Medicine

F. Benoit Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by F. Benoit in
Current site
Google Scholar
PubMed Close
,
A. Valentin Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by A. Valentin in
Current site
Google Scholar
PubMed Close
,
Y. Pelissier Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by Y. Pelissier in
Current site
Google Scholar
PubMed Close
,
F. Diafouka Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by F. Diafouka in
Current site
Google Scholar
PubMed Close
,
C. Marion Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by C. Marion in
Current site
Google Scholar
PubMed Close
,
D. Kone-Bamba Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by D. Kone-Bamba in
Current site
Google Scholar
PubMed Close
,
M. Kone Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by M. Kone in
Current site
Google Scholar
PubMed Close
,
M. Mallie Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by M. Mallie in
Current site
Google Scholar
PubMed Close
,
A. Yapo Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by A. Yapo in
Current site
Google Scholar
PubMed Close
, and
J.-M. Bastide Laboratoire d'Immunologie et Parasitologie, et Laboratoire de Pharmacognosie, Unite de Formation et de Recherche des Sciences Pharmaceutiques, Faculte de Pharmacie, Universite de Cote d'Ivoire, Montpellier, France

Search for other papers by J.-M. Bastide in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1996.54.67
Volume/Issue:
Volume 54: Issue 1
Page(s):
67–71
Restricted access
Get Permissions

Among strategies for the development of new antimalarials, a study of plants traditionally used in Africa against malaria has been pursued. Extracts obtained from the plants Azadirachta indica, Cinnamonum camphora, Lippia multiflora, Vernonia colorata, Guiera senegalensis, Combretum micranthum, and Ximenia americana, commonly used in Cote d'Ivoire by native healers for the treatment of malaria, were tested on two strains of Plasmodium falciparum: FcB1-Colombia (chloroquine-resistant) and F32-Tanzania (chloroquine-sensitive). Extracts were obtained after infusion and decoction, both techniques being used by most native healers. The antimalarial activities of the extracts were tested first by parasite 3H-hypoxanthine incorporation and second by visual evaluation of the activities of plant extracts on thin blood smears, which also permitted the determination of parasitic stages and parasite alteration. Among the seven plants tested, some had an apparent inhibitory effect on P. falciparum growth in vitro, while others seemed to be less efficient.

Author Notes

Copyright:
Copyright © 1996 by The American Society of Tropical Medicine and Hygiene 1996
Published Online:
Jan 1996
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 606 252 15
Full Text Views 41 1 1
PDF Downloads 40 1 1
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save