Maternal Trypanosoma cruzi-Specific Antibodies and Worsening of Acute Infection in Mouse Offspring

Silvana Marques De AraujoLaboratoire de Parasitologie et Unite Statistique-Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium

Search for other papers by Silvana Marques De Araujo in
Current site
Google Scholar
PubMed
Close
,
Maria Teresa RiveraLaboratoire de Parasitologie et Unite Statistique-Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium

Search for other papers by Maria Teresa Rivera in
Current site
Google Scholar
PubMed
Close
,
Ayachi El BouhdidiLaboratoire de Parasitologie et Unite Statistique-Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium

Search for other papers by Ayachi El Bouhdidi in
Current site
Google Scholar
PubMed
Close
,
Viviane De MaertelaerLaboratoire de Parasitologie et Unite Statistique-Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium

Search for other papers by Viviane De Maertelaer in
Current site
Google Scholar
PubMed
Close
, and
Yves CarlierLaboratoire de Parasitologie et Unite Statistique-Institut de Recherche Interdisciplinaire en Biologie Humaine et Nucleaire, Faculte de Medecine, Universite Libre de Bruxelles, Brussels, Belgium

Search for other papers by Yves Carlier in
Current site
Google Scholar
PubMed
Close
Restricted access

The role of antibodies in the previously demonstrated harmful effect of Trypanosoma cruzi-infected mothers on progeny infection was studied by injecting either serum from chronically infected animals or purified T. cruzi-specific antibodies into uninfected mice during gestation and lactation periods. It was verified that injected antibodies were transferred to offspring. Pregnant or lactating animals exhibited lower circulating antibody levels than nonpregnant or pregnant but nonlactating mice, respectively, suggesting that such antibody transfer occurred in both fetuses and suckling offspring. When infected two months after birth, offspring of mice treated with chronic serum or purified antibodies displayed significantly higher parasitemia than offspring from mothers receiving control serum or immunoglobulins unrelated to T. cruzi. These results indicate that soluble factors contained in sera of infected mice, and particularly antibodies, when transferred from mothers to their young, are able to worsen T. cruzi acquired infection in the offspring.

Save