Compliance with Antimalarial Chemoprophylaxis and the Subsequent Development of Malaria: A Matched Case-Control Study

Theresa W. GyorkosDivision of Clinical Epidemiology, Montreal General Hospital, Department of Epidemiology and Biostatistics, McGill University, McGill University Centre for Tropical Diseases, Montreal General Hospital, Montreal, Quebec, Canada

Search for other papers by Theresa W. Gyorkos in
Current site
Google Scholar
PubMed
Close
,
Jim E. SvensonDivision of Clinical Epidemiology, Montreal General Hospital, Department of Epidemiology and Biostatistics, McGill University, McGill University Centre for Tropical Diseases, Montreal General Hospital, Montreal, Quebec, Canada

Search for other papers by Jim E. Svenson in
Current site
Google Scholar
PubMed
Close
,
J. Dick MacleanDivision of Clinical Epidemiology, Montreal General Hospital, Department of Epidemiology and Biostatistics, McGill University, McGill University Centre for Tropical Diseases, Montreal General Hospital, Montreal, Quebec, Canada

Search for other papers by J. Dick Maclean in
Current site
Google Scholar
PubMed
Close
,
Nashila MohamedDivision of Clinical Epidemiology, Montreal General Hospital, Department of Epidemiology and Biostatistics, McGill University, McGill University Centre for Tropical Diseases, Montreal General Hospital, Montreal, Quebec, Canada

Search for other papers by Nashila Mohamed in
Current site
Google Scholar
PubMed
Close
,
Martine H. RemondinDivision of Clinical Epidemiology, Montreal General Hospital, Department of Epidemiology and Biostatistics, McGill University, McGill University Centre for Tropical Diseases, Montreal General Hospital, Montreal, Quebec, Canada

Search for other papers by Martine H. Remondin in
Current site
Google Scholar
PubMed
Close
, and
Eliane D. FrancoDivision of Clinical Epidemiology, Montreal General Hospital, Department of Epidemiology and Biostatistics, McGill University, McGill University Centre for Tropical Diseases, Montreal General Hospital, Montreal, Quebec, Canada

Search for other papers by Eliane D. Franco in
Current site
Google Scholar
PubMed
Close
Restricted access

To determine if there is a difference in compliance with antimalarial chemoprophylaxis between febrile travelers with and without malaria, 157 patients with malaria, a history of fever, and recent travel to a malariaendemic area were compared with 157 matched controls. Antimalarial prophylaxis had been taken by 48% of all patients. Chemoprophylaxis use was correlated with region and purpose of travel. Cases were less likely to have taken prophylaxis (53%) than controls (76%) (odds ratio = 0.35, confidence interval = 0.27, 0.73), even after controlling for region of travel, purpose of travel, and previous exposure to malaria. Chemoprophylaxis was effective in reducing malaria risk. Travel agents and health practitioners should provide all travelers to malaria-endemic areas with adequate information about chemoprophylaxis and its importance.

Save