Efficacy of Ciprofloxacin in Enteric Fever: Comparison of Treatment Duration in Sensitive and Multidrug-Resistant Salmonella

M. N. Alam Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by M. N. Alam in
Current site
Google Scholar
PubMed Close
,
S. A. Haq Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by S. A. Haq in
Current site
Google Scholar
PubMed Close
,
K. K. Das Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by K. K. Das in
Current site
Google Scholar
PubMed Close
,
P. K. Baral Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by P. K. Baral in
Current site
Google Scholar
PubMed Close
,
M. N. Mazid Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by M. N. Mazid in
Current site
Google Scholar
PubMed Close
,
R. U. Siddique Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by R. U. Siddique in
Current site
Google Scholar
PubMed Close
,
K. M. Rahman Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by K. M. Rahman in
Current site
Google Scholar
PubMed Close
,
Z. Hasan Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by Z. Hasan in
Current site
Google Scholar
PubMed Close
,
M. A. S. Khan Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by M. A. S. Khan in
Current site
Google Scholar
PubMed Close
, and
P. Dutta Department of Medicine, and Department of Microbiology, Institute of Postgraduate Medicine and Research, Department of Medicine, Cornell University Medical College, Memorial Sloan-Kettering Cancer Center, Medical Services Department, Beximco Pharmaceuticals Limited, Dhaka, Bangladesh

Search for other papers by P. Dutta in
Current site
Google Scholar
PubMed Close
DOI:
https://doi.org/10.4269/ajtmh.1995.53.306
Volume/Issue:
Volume 53: Issue 3
Page(s):
306–311
Restricted access
Get Permissions

The efficacy of two regimens of ciprofloxacin was compared in a randomized study conducted on 69 patients with enteric fever, 52.2% of whom had infection with multidrug-resistant (MDR) strains of Salmonella typhi or S. paratyphi. Patients were randomly assigned to two regimens (10 days versus 14 days) of ciprofloxacin (500 mg twice a day). The mean ± SD time required for defervescence was similar for both regimens (4.2 ± 1.9 days in the 10-day group and 4.9 ± 2.6 days in the 14-day group). A 100% cure was observed in each treatment group and no serious side effects were observed. Relapse occurred in two patients (14-day regimen). Only one patient (14-day regimen) had growth of S. typhi in stool culture at the time of the first follow-up three days after completion of therapy. Follow-up studies on available patients on two, six, and 12 months after completion of therapy revealed that all patients had negative stool cultures for S. typhi and S. paratyphi. This study indicates that ciprofloxacin may be recommended as an initial therapy for enteric fever for adult men and nonpregnant and nonlactating women in areas where MDR strains of S. typhi and S. paratyphi are prevalent, and that 500 mg twice a day of the drug given for 10 days is as effective as 14 days at the same dosage.

Author Notes

Copyright:
Copyright © 1995 by The American Society of Tropical Medicine and Hygiene 1995
Published Online:
Sep 1995
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Past two years Past Year Past 30 Days
Abstract Views 3856 3252 64
Full Text Views 28 4 0
PDF Downloads 32 0 0
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save