Short Report: A Placebo-Controlled Study of Lactobacillus GG Colonization in One-to-Three-Year-Old Peruvian Children

Patricia SheenAsociacion Benefica PRISMA (Proyectos en Informatica Salud, Medicina y Agricultura), Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, Universidad Peruana Cayetano Heredia, Department of International Health, Johns Hopkins School of Hygiene and Public Health, San Borja, Lima, Peru

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Richard A. OberhelmanAsociacion Benefica PRISMA (Proyectos en Informatica Salud, Medicina y Agricultura), Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, Universidad Peruana Cayetano Heredia, Department of International Health, Johns Hopkins School of Hygiene and Public Health, San Borja, Lima, Peru

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Robert H. GilmanAsociacion Benefica PRISMA (Proyectos en Informatica Salud, Medicina y Agricultura), Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, Universidad Peruana Cayetano Heredia, Department of International Health, Johns Hopkins School of Hygiene and Public Health, San Borja, Lima, Peru

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Lilly CabreraAsociacion Benefica PRISMA (Proyectos en Informatica Salud, Medicina y Agricultura), Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, Universidad Peruana Cayetano Heredia, Department of International Health, Johns Hopkins School of Hygiene and Public Health, San Borja, Lima, Peru

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Manuela VerasteguiAsociacion Benefica PRISMA (Proyectos en Informatica Salud, Medicina y Agricultura), Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, Universidad Peruana Cayetano Heredia, Department of International Health, Johns Hopkins School of Hygiene and Public Health, San Borja, Lima, Peru

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Guillermo MadicoAsociacion Benefica PRISMA (Proyectos en Informatica Salud, Medicina y Agricultura), Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, Universidad Peruana Cayetano Heredia, Department of International Health, Johns Hopkins School of Hygiene and Public Health, San Borja, Lima, Peru

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A pilot, placebo-controlled study conducted in Peruvian toddlers in a periurban shanty-town community demonstrates that 1) a simple fluorescent antibody test performed on bacteria from colonies grown on solid culture media can be used as a presumptive screening tool for Lactobacillus GG, 2) Lactobacillus GG powder sprinkled on flavored gelatin as a nutritional supplement is well-accepted by infants and mothers in this population, and 3) daily doses of Lactobacillus GG result in efficient colonization of the gastrointestinal tract of Peruvian infants. This study demonstrates that Lactobacillus GG should be evaluated as an adjunct for diarrhea control programs at the community level as well as in hospital-based settings.

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