Familial Aggregation of Leishmania chagasi Infection in Northeastern Brazil

Pedro H. CabelloDepartment of Genetics, Oswaldo Cruz Institute, Laboratory of Medical Genetics, Federal University of Bahia, Department of Parasitology, University of Sao Paulo, Rio de Janeiro, Brazil

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Angela Maria V. M. Dias LimaDepartment of Genetics, Oswaldo Cruz Institute, Laboratory of Medical Genetics, Federal University of Bahia, Department of Parasitology, University of Sao Paulo, Rio de Janeiro, Brazil

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Eliane S. AzevedoDepartment of Genetics, Oswaldo Cruz Institute, Laboratory of Medical Genetics, Federal University of Bahia, Department of Parasitology, University of Sao Paulo, Rio de Janeiro, Brazil

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Henrique KriegerDepartment of Genetics, Oswaldo Cruz Institute, Laboratory of Medical Genetics, Federal University of Bahia, Department of Parasitology, University of Sao Paulo, Rio de Janeiro, Brazil

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A sample of 1,604 individuals belonging to 243 nuclear families from an endemic area of visceral leishmaniasis (Jacobina, Bahia State, Brazil) was studied to disclose the intrafamilial pattern of infection. Significant father to offspring, mother to offspring, and sibling to sibling associations, in contrast a with nonsignificant father to mother association, clearly indicate a familial aggregation of the infection, with a strong suggestion of at least partial genetic involvement.

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