Author:
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 604 | 204 | 14 |
| Full Text Views | 13 | 1 | 0 |
| PDF Downloads | 10 | 0 | 0 |
Immune Complexes and Nephropathies Associated with Plasmodium Inui Infection in the Rhesus Monkey
Laila F. Nimri
Laila F. Nimri
Department of Biological Sciences, Jordan University of Science and Technology, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, Irbid, Jordan
Search for other papers by Laila F. Nimri in
Current site
Google Scholar
PubMed
Search for other papers by Laila F. Nimri in
Current site
Google Scholar
PubMed
Norbert H. Lanners
Norbert H. Lanners
Department of Biological Sciences, Jordan University of Science and Technology, Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, Irbid, Jordan
Search for other papers by Norbert H. Lanners in
Current site
Google Scholar
PubMed
Search for other papers by Norbert H. Lanners in
Current site
Google Scholar
PubMed
The pathogenesis of renal diseases associated with Plasmodium malariae infections is still not fully understood. The present work is concerned with the infection caused by P. inui in the rhesus monkey Macaca mulatta as a potential model for human quartan malaria, which the monkey parasite resembles in morphology and schizogonic behavior. Various aspects of the disease were studied. Changes in the levels of serum complement components C3 and C4 indicate activation of complement through the classical pathway. A few days after infection, IgG antibody titers increased, coinciding with low levels of parasitemia, which suggests that some of these antibodies are protective. Immunofluorescence testing of kidney tissue showed a predominance of IgM antibodies over IgG, C3, C4, albumin, and fibrinogen, which was detected in a number of the infected monkeys. These findings were consistent with those seen in humans with P. malariae infection and indicate that the P. inui/rhesus monkey model is likely to be appropriate for the study of different aspects of quartan malaria.
Author Notes
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 604 | 204 | 14 |
| Full Text Views | 13 | 1 | 0 |
| PDF Downloads | 10 | 0 | 0 |