Comparison of Micronized Halofantrine with Chloroquine-Antibiotic Combinations for Treating Plasmodium falciparum Malaria in Adults from Gabon

Peter G. Kremsner International Research Laboratory of the Albert-Schweitzer-Hospital, Landesinstitut fur Tropenmedizin, Department of Infectious Diseases, University of Vienna, BP 118 Lambarene, Gabon

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Eckart Wildling International Research Laboratory of the Albert-Schweitzer-Hospital, Landesinstitut fur Tropenmedizin, Department of Infectious Diseases, University of Vienna, BP 118 Lambarene, Gabon

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Lars Jenne International Research Laboratory of the Albert-Schweitzer-Hospital, Landesinstitut fur Tropenmedizin, Department of Infectious Diseases, University of Vienna, BP 118 Lambarene, Gabon

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Wolfgang Graninger International Research Laboratory of the Albert-Schweitzer-Hospital, Landesinstitut fur Tropenmedizin, Department of Infectious Diseases, University of Vienna, BP 118 Lambarene, Gabon

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Ulrich Bienzle International Research Laboratory of the Albert-Schweitzer-Hospital, Landesinstitut fur Tropenmedizin, Department of Infectious Diseases, University of Vienna, BP 118 Lambarene, Gabon

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DOI:
https://doi.org/10.4269/ajtmh.1994.50.790
Volume/Issue:
Volume 50: Issue 6
Page(s):
790–795
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Multidrug resistance of Plasmodium falciparum is spreading throughout Africa. In Lambarene, Gabon where chloroquine-resistant malaria is prevalent, a randomized comparative trial with three regimens for treating P. falciparum malaria in adults was performed. One hundred two patients evaluated received either a new micronized formulation of halofantrine (8 mg/kg every 6 hr in three doses) (group H) or chloroquine (25 mg/kg for a 48-hr period) plus clindamycin (5 mg/kg every 12 hr in six doses) (group CCI), or chloroquine (as above) plus doxycycline (2 mg/kg every 12 hr in six doses) (group CD). All treatment regimens were well-tolerated. In group H, 100% of the patients were cured, and in group CCI, 97% of the patients were cured by day 28 of follow-up. In group CD, a significantly lower cure rate of 75% (P < 0.01) and a slower parasite clearance was observed, but only low grade (RI) resistance occurred.

Author Notes

Copyright:
Copyright © 1994 by The American Society of Tropical Medicine and Hygiene 1994
Published Online:
Jun 1994
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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