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Enumeration of Selected Leukocytes in the Small Intestine of BALB/c Mice Infected with Cryptosporidium Parvum
Y. Boher
Y. Boher
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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I. Perez-Schael
I. Perez-Schael
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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G. Caceres-Dittmar
G. Caceres-Dittmar
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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G. Urbina
G. Urbina
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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R. Gonzalez
R. Gonzalez
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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G. Kraal
G. Kraal
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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F. J. Tapia
F. J. Tapia
Instituto de Biomedicina, Universidad Central de Venezuela, Department of Histology, Free University of Amsterdam, Caracas, Venezuela
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Neonatal, suckling BALB/c mice inoculated with Cryptosporidium parvum produce an infection characterized by continuous shedding of oocysts that spontaneously clears by the time the animals are three weeks of age. Neonatal mice were used to characterize the leukocyte subgroups present in Peyer's patches from the ileum and jejunum of Cryptosporidium-infected and healthy mice. After infection, ileal Peyer's patches showed a predominant CD8+ response, with abundant monocytes-macrophages (MOMA-2+) and nonlymphoid dendritic cells (NLDC-145+ cells). In contrast, jejunal Peyer's patches showed more T lymphocytes than ileal patches, with a predominance of CD4+ cells and many dendritic NLDC-145+ cells and MOMA-2+ cells. The present results showed that ileal and jejunal Peyer's patches are functionally different in response to Cryptosporidium parasites. These findings suggest a preferential involvement of jejunal Peyer's patches in T cell-dependent immunity against the parasite, whereas ileal patches may be associated with B cell expansion and maturation.
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