The China I/CDC Strain of Plasmodium malariae in Aotus Monkeys and Chimpanzees

William E. Collins Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Hans O. Lobel Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Harold McClure Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Elizabeth Strobert Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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G. Gale Galland Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Frances Taylor Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Alba L. Barreto Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Ronald R. Roberto Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Jimmie C. Skinner Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Samuel Adams Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Carla L. Morris Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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JoAnn Sullivan Malaria Branch, Division of Parasitic Diseases and Scientific Resources Program, Center for Infectious Diseases, Centers for Disease Control and Prevention, Yerkes Regional Primate Research Center, Emory University, Bureau of Communicable Disease Control, Department of Public Health, Bureau of Epidemiology and Disease Control, California Department of Health Services, Atlanta, Georgia

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Five Aotus monkeys and two chimpanzees were infected with Plasmodium malariae isolated from a patient who acquired her infection approximately 50 years ago. All animals were splenectomized. The chimpanzees supported the highest parasite densities of 22,271/µl and 18,544/µl. Three Aotus monkeys with a previous history of infection with P. vivax had maximum parasite counts of from 1,818/µl to 2,909/µl, whereas two monkeys not previously infected had maximum parasite counts of 6,908/µl. The establishment of new isolates in these animals aides the development of diagnostic probes and the identification of areas of antigenic variation within the species.

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