Studies of Dengue Fever Virus (Hawaii Mouse Adapted) in Lactating Hamsters

Reginald L. ReaganVirus Laboratory, Live Stock Sanitary Service, University of Maryland, College Park, Maryland

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Frances S. YanceyVirus Laboratory, Live Stock Sanitary Service, University of Maryland, College Park, Maryland

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A. L. BruecknerVirus Laboratory, Live Stock Sanitary Service, University of Maryland, College Park, Maryland

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Summary

From this observation it appears that dengue fever virus (Hawaii mouse adapted) may be transmitted from lactating hamsters to suckling hamsters. None of the mothers showed symptoms of nervous system involvement over a 21 day observation period. Mouse tests of their brains were negative. Four out of 32 suckling hamsters developed symptoms of nervous system involvement and their brains were shown to contain dengue fever virus by neutralization tests conducted intracerebrally in Swiss albino mice. The control sucklings and sucklings from the exposed mothers showing no signs of central nervous system involvement were sacrificed and their brains tested by the intracerebral mouse test, but no virus was demonstrated.

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