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Influence of the Amino Nucleoside of Puromycin on the Course and Pathology of Trypanosome Infections in Rabbits and Mice
Eleanor Johnson Tobie
Eleanor Johnson Tobie
Public Health Service, National Institutes of Health, Bethesda, Maryland
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Benjamin Highman
Benjamin Highman
Public Health Service, National Institutes of Health, Bethesda, Maryland
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Summary
The amino nucleoside of Puromycin was tested for its trypanocidal activity against Trypanosoma congolense, T. equinum, T. gambiense, and T. rhodesiense infections in mice and T. gambiense in rabbits. Data reported show that the drug was somewhat effective against T. congolense only when a small inoculum was used but was highly effective against the other species especially T. gambiense. By treating mice following each of a series of relapses it was not possible to produce true resistance to the drug but it was possible, due to the prolonged course of the infection, to produce changes in the central nervous system of the mouse comparable to those produced by trypanosomiasis in man.
Author Notes
National Microbiological Institute, Laboratory of Tropical Diseases.
National Institutes of Arthritis and Metabolic Diseases, Laboratory of Pathology and Histochemistry.
With the technical assistance of Harvey D. James, Jr.
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