Selectivity of Human T Lymphotropic Virus Type-1 (HTLV-1) and HTLV-2 Infection Among Different Populations in Brazil

A. A. Gabbai Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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J. O. Bordin Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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J. P. B. Vieira-Filho Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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A. Kuroda Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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A. S. B. Oliveira Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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M. V. Cruz Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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A. A. F. Ribeiro Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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S. R. Delaney Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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D. R. Henrard Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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J. Rosario Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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G. C. Roman Escola Paulista de Medicina, Abbott Laboratories, Neuroepidemiology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Sao Paulo , Brazil

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DOI:
https://doi.org/10.4269/ajtmh.1993.49.664
Volume/Issue:
Volume 49: Issue 6
Page(s):
664–671
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A seroprevalence study for human T lymphotropic virus type-1 (HTLV-1) and HTLV-2 was conducted in Sao Paulo, Brazil among 2,312 individuals that included following groups: 1,148 volunteer blood donors, 37 patients with tropical spastic paraparesis (TSP), 53 with lymphoproliferative disorders, 171 with a history of multiple blood transfusions, 268 human immunodeficiency virus type-1 (HIV-1) seropositive subjects, and 635 Amazonian Indians. Antibodies to HTLV-1/2 were screened by enzyme-linked immunosorbent assay (ELISA) and confirmed by Western blot and/or radioimmunoprecipitation. The differentiation of HTLV-1 and HTLV-2 was achieved using a synthetic recombinant peptide (rgp46) ELISA. We confirmed the presence of HTLV-1 infection in Brazil, both in blood donors (0.4%) and in patients exposed to blood transfusions (2.9%), as well as the occurrence of HTLV-1-associated TSP (11 patients, or 30% of all TSP cases) and adult T cell leukemia/lymphoma (two cases, or 3.5% of all hematologic malignancies). The HIV-1 infected individuals were shown to be coinfected (8.9%) with either HTLV-1 or HTLV-2. All HIV-1 and HTLV-2 coinfected individuals were intravenous drug abusers. In addition, we also demonstrated the presence of HTLV-2 (4.7%), and HTLV-1/2 (0.8%) in tribes of Amazonian Indians who lived in the eastern Amazon basin (southeastern State of Para). The selectivity of these retroviral infections in particular groups is emphasized, as well as the need for HTLV-1/2 screening of all blood donors in Brazil as a public health measure.
Copyright:
Copyright © 1993 by The American Society of Tropical Medicine and Hygiene 1993
Published Online:
Dec 1993
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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