Antigenic Comparison of Ockelbo Virus Isolates from Sweden and Russia with Sindbis Virus Isolates from Europe, Africa, and Australia: Further Evidence for Variation Among Alphaviruses

Jan O. Lundstrom National Bacteriological Laboratory, Karolinska Institute, National Defense Research Establishment, Pasteur Merieux SV, Stockholm, Sweden

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Sirkka Vene National Bacteriological Laboratory, Karolinska Institute, National Defense Research Establishment, Pasteur Merieux SV, Stockholm, Sweden

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Jean-Francois Saluzzo National Bacteriological Laboratory, Karolinska Institute, National Defense Research Establishment, Pasteur Merieux SV, Stockholm, Sweden

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Bo Niklasson National Bacteriological Laboratory, Karolinska Institute, National Defense Research Establishment, Pasteur Merieux SV, Stockholm, Sweden

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DOI:
https://doi.org/10.4269/ajtmh.1993.49.531
Volume/Issue:
Volume 49: Issue 5
Page(s):
531–537
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The plaque-reduction neutralization test (PRNT) was used to compare 15 isolates of Ockelbo virus from Sweden, one isolate of Ockelbo virus from Russia, the Egyptian prototype Sindbis virus, and Sindbis-like viruses from Slovakia, South Africa, Cameroon, and Australia. Strains from northern Europe (Sweden and Russia) were indistinguishable by PRNT. We observed some antigenic variation between isolates of Sindbis virus from Europe, Africa, and Australia. An Australian strain (C-377) was shown to be distinct from prototype Sindbis virus, and the Acrocephalus strain from Slovakia was shown to be identical to prototype Sindbis virus. All other strains, including Ockelbo virus isolates, were shown to be subtypes of prototype Sindbis virus.
Published Online:
Nov 1993
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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