Morphologic Effects of Artemisinin in Plasmodium Falciparum

Yoshimasa Maeno Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Tetsuhiko Toyoshima Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Hisashi Fujioka Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Yoshihiro Ito Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Steven R. Meshnick Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Achille Benakis Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Wilbur K. Milhous Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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Masamichi Aikawa Institute of Pathology, Case Western Reserve University, Department of Epidemiology, School of Public Health, University of Michigan, Department of Pharmacology, University of Geneva, Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Cleveland, Ohio, Switzerland

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DOI:
https://doi.org/10.4269/ajtmh.1993.49.485
Volume/Issue:
Volume 49: Issue 4
Page(s):
485–491
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Ultrastructural changes induced in Plasmodium falciparum by artemisinin were studied in vitro. Electron microscopic autoradiography was performed on infected erythrocytes that were exposed in vitro to 3H-dihydroartemisinin and 14C-artemisinin. These drugs consistently were located in food vacuoles and mitochondria. Two hours after administration, changes were observed in parasite mitochondria, rough endoplasmic reticulum, and nuclear envelope. At four hours, in addition to the earlier changes, nuclear membranes and, to a lesser extent, some plasma membranes formed myelin figures. In addition, there was a disappearance of ribosomes, and a destruction of food vacuole membranes. These changes may lead to the total disorganization of the parasites. Approximately 30% of the parasites manifested these alterations.
Copyright:
Copyright © 1993 by The American Society of Tropical Medicine and Hygiene 1993
Published Online:
Oct 1993
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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