Prevalence of Hepatitis C Viral Antibody in Transfused and Nontransfused Egyptian Children

A. S. KhalifaFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by A. S. Khalifa in
Current site
Google Scholar
PubMed
Close
,
Benjamin S. MitchellFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Benjamin S. Mitchell in
Current site
Google Scholar
PubMed
Close
,
Douglas M. WattsFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Douglas M. Watts in
Current site
Google Scholar
PubMed
Close
,
Mona H. El-SamahyFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Mona H. El-Samahy in
Current site
Google Scholar
PubMed
Close
,
Manal H. El-SayedFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Manal H. El-Sayed in
Current site
Google Scholar
PubMed
Close
,
Nassef F. HassanFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Nassef F. Hassan in
Current site
Google Scholar
PubMed
Close
,
Gerald B. JenningsFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Gerald B. Jennings in
Current site
Google Scholar
PubMed
Close
,
Richard G. HibbsFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Richard G. Hibbs in
Current site
Google Scholar
PubMed
Close
, and
Andrew L. CorwinFaculty of Medicine, Ain Shams University, U.S. Naval Medical Research Unit No. 3 (NAMRU-3), U.S. Naval Medical Research Unit No. 2 (NAMRU-2), Naval Environmental Health Center, Cairo, Egypt

Search for other papers by Andrew L. Corwin in
Current site
Google Scholar
PubMed
Close
Restricted access

Hepatitis C (HCV) virus is recognized as the major cause of what was previously referred to as parenterally acquired (blood-mediated) non-A, non-B hepatitis. A study involving 252 transfused and nontransfused Egyptian children was conducted from November 1990 through February 1991 to determine the prevalence of HCV and the role of blood and blood and blood product transfusions in the spread of the virus. Serum specimens were assayed by a second generation enzyme immunoassay and were considered reactive only after supplemental testing using the second generation recombinant immunoblot assay. Prevalence among 84 young study subjects with hematologic disorders was 55% (46 of 84), while no HCV antibodies were detected among the two nonhematologic pediatric populations studied: 84 hospital admissions and 84 acutely ill but otherwise healthy outpatients (seeking treatment for symptoms associated with a new condition less than three weeks old in the absence of any chronic health problem). Ninety-two percent (77 of 84) of the hematology-related cases had medical histories of multiple transfusions. Positive antibody responses (46) were significantly associated with increased duration of illness (P < 0.001) and the volume and number of transfusions (P < 0.01) when compared with negative ones (38). However, prior hospitalization and/or surgery were not related to HCV antibody status. The high prevalence of HCV antibody among multiply transfused infants and children suggests that blood and blood product supplies should be regularly screened for HCV antibody.

Save