Treatment of Malaria in Vietnam with Oral Artemisinin

Nguyen Duy SyInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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Dao Boi HoanInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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Nguyen Phuong DungInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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Nguyen Van HuongInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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Le Nguyen BinhInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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Mai Van SonInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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Steven R. MeshnickInstitute of Malaria, Parasitology and Entomology, Vietnamese Science Institute, Center of Ecology and Resources and Center of Natural Products, Department of Epidemiology, University of Michigan School of Public Health, Hanoi and Ho Chi Minh City, Vietnam

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In this study, 638 patients with either Plasmodium falciparum or P. vivax malaria were treated with artemisinin (qinghaosu) that was isolated and formulated into tablets and capsules in Vietnam. In all cases, artemisinin treatment resulted in a rapid clearance of parasitemia and fever. Recrudescence rates were highest in those groups receiving treatment for five or less days (50%), but were between 10% and 23% for those groups receiving the drug for 5–10 days. A low recrudescent rate (9.5%) was also found when patients were treated with a combination of artemisinin for three days and tetracycline for five days. Thus, artemisinin represents a useful and economically feasible component of the malaria control program in Vietnam.

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